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PRÉNUMBRA® is a liquid (non-solid) injectable formulation of afamelanotide designed for administration by a healthcare professional and intended to provide a flexible dose of afamelanotide, a synthetic analogue of natural α-melanocyte stimulating hormone.

Pre-clinical and clinical studies have shown afamelanotide to be effective in targeting various organ systems with potential to address a number of disorders. The development of PRÉNUMBRA® will evaluate the safety and efficacy of afamelanotide in acute and systemic diseases, specifically as a potent vasoactive drug which counteracts fluid formation in tissues.