Research

Clinuvel has conducted over 15 trials of SCENESSE® (afamelanotide) in over 600 patients, published research from which can be purchased online.

Below is a selection of published research on SCENESSE®.

• Grimes PE, Hamzavi I, Lebwoh M, Ortonne JP & Lim HW, (2012). "The Efficacy of Afamelanotide and Narrowband UV-B Phototherapy for Repigmentation of Vitiligo." Arch Derm. Oct 15 [Epub ahead of print].
• Böhm M, Ehrchen J & Luger TA, (2012). "Beneficial effects of the melanocortin analogue Nle(4) -d-Phe(7) -α-MSH in acne vulgaris." JEADV. July 27 [Epub ahead of print].
• Haylett AK, Nie Z, Brownrigg M, Taylor R, E Rhodes L, (2010). "Systemic photoprotection in solar urticaria with α-melanocyte stimulating hormone analogue [Nle(4) -D-Phe(7) ]-α-MSH." Br J Dermatol. 164(2):407-14.
• Minder, EI (2010). "Afamelanotide". Drugs of the Future. 35(5): 365.
• Harms JH, Lautenschlager S, Minder CE, Minder EI, (2009). “Mitigating photosensitivity of erythropoietic protoporphyria patients by an agonistic analog of alpha-melanocyte stimulating hormone.” Photochem Photobiol 85(6):1434-9.
• Harms, J et al., (2009), ‘An alpha-melanocyte-stimulating hormone analogue in erythropoietic protoporphyria’, New England Journal of Medicine, 360(3):306-307.
• Barnetson R, et al, (2006). “[Nle⁴-D-Phe⁷]-alpha-Melanocyte-Stimulating Hormone Significantly Increased Pigmentation and Decreased UV Damage in Fair-Skinned Caucasian Volunteers.” Journal of Investigative Dermatology 126, 1869–1878.
• Hadley ME, Dorr RT, (2006). “Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization.” Peptides 27(4):921-30. Epub 2006 Jan 18.
• Fitzgerald LM, Fryer JL, Dwyer T, Humphrey SM, (2006). “Effect of [Nle(4), D-Phe(7)]-alpha-MSH, on melanin synthesis in humans with MC1R variant alleles.” Peptides 27(2):388-94. Epub 2005 Nov 15.
• Dorr RT, et al, (2000). “Increased eumelanin expression and tanning is induced by a superpotent melanotropin [Nle4-D-Phe7]-alpha-MSH in humans.” Photochem Photobiol 72(4):526-32.
• Levine N, et al (1999). “Effects of a potent synthetic melanotropin, Nle4-D-Phe7-α-MSH (Melanotan-I) on tanning: a dose-ranging study.” Journal of Dermatological Treatment 10(2):127-32.

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Over 200 articles have been published on afamelanotide (chemical name [Nle⁴, D-Phe⁷]α-MSH or NDP-MSH).