Low sunscreen use, high melanoma rates: a breakdown of the sunsmart message?

Tuesday, January 24th, 2012

Image from Flickr.com by MuffetIt’s estimated that more than 9,000 Americans will die from melanoma this year and 76,000 new cases of the disease will be diagnosed. Melanoma, an aggressive skin cancer which can spread (metastasize) quickly to other parts of the body, is also the second most common form of cancer in young Americans (those aged 15-29).

Overexposure of skin to ultraviolet (UV) radiation significantly increases an individual’s risk of melanoma, particularly at a young age; just one severe sunburn in childhood can double the lifetime risk of melanoma. Sun protective measures such as clothing and sunscreen are seen as key to reducing melanoma risk. (more…)

Sun protection: Appearance is a greater incentive than health for young people

Monday, November 21st, 2011

According to the U.S. Preventative Services Task Force (USPSTF), the best way to deter teens and young adults from overexposure to the sun is to demonstrate the effects ultraviolet (UV) radiation can have on their appearance.

The USPSTF, an independent panel of experts assigned to provide recommendations on an array of health prevention issues, looked at evidence indicating behavioural counselling could help to prevent skin cancer. The newly released recommendations, an update of the 2003 statement, suggest that teens’ behaviour can indeed be changed through counselling; particularly that which highlights the physical changes UV radiation causes to skin, such as premature aging and wrinkling. (more…)

Ultraviolet A more cancer-causing than once thought

Tuesday, October 18th, 2011

While the evidence linking sunbeds to the development of skin cancer continues to mount, recent research provides new insight into the underlying mechanisms.

Radiation from both the sun and tanning beds is made up of various wavelengths, including visible light and several types of ultraviolet (UV) radiation. Ultraviolet B (UVB) rays, those which cause sunburn, have long been heralded the culprit which initiates skin cancer. It does this by damaging the genetic information (DNA) within skin cells, forming lesions known as cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone photoproducts (6-4PPs). These lesions create mutations in the DNA which can lead to the development of skin cancer (you can read about this process here). (more…)

Children at greater risk of melanoma spreading

Tuesday, October 11th, 2011

A recent study of melanoma in children and young adults indicates that there may be greater risk of metastasis, or spread, of the cancer in younger patients. The study, conducted by researchers at Baltimore’s John Hopkins Children’s Center, involved analysis of 2008 SEER (Surveillance, Epidemiology, and End Results) data on melanoma cases from 2003 to 2008. A total of 717 children and 1368 adults, aged 20-24, were diagnosed during this time.

Investigators looked at patients who received biopsies of the sentinel lymph nodes (SLN; those nearby the initial tumour) and the number of those in whom the disease had spread to this site. It was found that, of those biopsied, children were more likely to have cancer cells which had infiltrated the removed lymph nodes (25%), indicating greater rates of metastases than in adult patients (14%). (more…)

The diverse roles of alpha-melanocyte-stimulating hormone

Friday, July 1st, 2011

Melanogenesis - click to enlarge

When skin is exposed to sunlight, ultraviolet (UV) radiation stimulates the production and release of a hormone, alpha melanocyte stimulating hormone, or α-MSH. Alpha-MSH is secreted by keratinocytes, a specific type of skin cell, then binds to receptors on the surface of another type of cell, called a melanocyte. When α-MSH binds to the receptors, which are known as MC1R, it activates the melanocytes to produce the brown/black pigment melanin. The melanin is subsequently transferred back the keratinocytes, increasing the level of melanin within the epidermis, the outer layer of the skin.

Melanin is a photoprotective to skin cells (protecting them from light/UV radiation) and the greater its density in the epidermis, the more protection is given to the layers of skin below. It does this by absorbing, reflecting and refracting light (particularly UV radiation) and preventing it from penetrating to the nucleus of keratinocytes or to lower levels of the skin. Melanin is also believed to play a role in scavenging free radicals, which can injure skin cells, and in facilitating UV induced apoptosis (programmed cell death), which removes damaged cells. Thus, melanin’s protective role goes beyond providing a physical barrier. It has been suggested that the 2-3 fold melanin levels seen in darker skin types, compared to lighter skin types, convey up to 100-fold difference in sensitivity to ultraviolet radiation due to these protective functions (see Rees 2004).

(more…)

Ultraviolet radiation and its effects on the skin

Wednesday, June 22nd, 2011

Ultraviolet (UV) radiation forms part of the electromagnetic spectrum between visible light and X-rays; it is invisible to the human eye. UV light can be separated into three bands, UVA (400-320nm), UVB (320-290nm) and UVC (290-100nm). Of the UV radiation that reaches the Earth’s surface from the sun, approximately 6% is UVB and 94% UVA.

Skin maintains a curious balance with UV radiation. When UV impacts upon skin, the various wavelengths of light penetrate to different levels and thus have a number of effects.

(more…)

Cellular messaging leading to melanin production

Tuesday, June 7th, 2011

Each cell within the body has one or more receptors; molecules on or within the cell to which other molecules, called ligands, bind. This binding causes a series of chemical reactions within the cell, called a ‘signaling pathway’. Signaling pathways are responsible for cellular responses, allowing other cells and external elements to alter how a cell functions. There are two types of ligands which bind to receptors: agonists, which then promote a response in the pathway, and antagonists, which lead to an alternate response. (more…)

“Solariums make a mockery of our efforts to reduce skin cancer”: Cancer Council Australia

Monday, May 16th, 2011

Cancer Council Australia has launched one of the strongest public attacks to date on the use and regulation of sunbeds in the country. This follows a report that some solarium devices emit UV radiation six times stronger than the sun at midday in Australia.

In a press release issued today, the CEO of Cancer Council Australia, Professor Ian Olver, cited a paper published in this month’s Photochemistry and Photobiology journal when calling for the Australian Government to phase out solariums. (more…)

Dear 16-year-old Me

Thursday, May 5th, 2011

A great new viral video from the David Cornfield Melanoma Fund went live earlier this week. Check it out:

 

 

Head to the DCMF website for more on their work. You can read more about melanoma on our website.

How does indoor tanning cause skin cancer?

Wednesday, April 6th, 2011

Tanning causes skin cancerEarlier today, new stats were published by Cancer Research UK highlighting that two young adult Britons are diagnosed with skin cancer every day; a rate which has tripled since the 1970s. There were several factors highlighted as contributing to this increase, but one was most clearly singled out in the release:

“using a sunbed before the age of 35 can increase your risk of melanoma by 75%”

(more…)