The evolution of human skin pigmentation: The delicate balance

Friday, July 16th, 2010

Skin colour is one of the most obvious and most variable traits humans possess. As visual creatures, people readily observe these differences in one another.  Anthropologist, Dr. Nina Jablonski, and colleague George Chaplin have unraveled the mystery behind the diversity of this distinguishing characteristic in their article, ‘Human skin pigmentation as an adaptation to UV radiation’. The pair have presented the first complete theory of skin colour as an evolutionary adaptation.

Paeleotologists have long known that human ancestors once had bodies covered with dense hair. Several theories on the evolution of the present ‘hairless condition’ exist. In this case, the authors suggest this was in response to hot conditions and the need to lose body heat upon physical activity. As naked beings, their once-protected skin became exposed to a multitude of environmental elements, including abrasion, infection, various chemicals and weather conditions. At the same time as the disappearance of the majority of body hair, humans evolved skin that was a more resilient barrier to such hazards and also contained the protective pigment eumelanin (melanin).

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Summary of today’s announcements

Wednesday, July 14th, 2010

Today’s announcement of the results of CUV017 has brought with it a stream of updates from Clinuvel, on the website, YouTube and beyond.

In this post we summarise the days releases and developments.

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Sex and sport impact sun protective behaviour and skin cancer risk

Thursday, June 10th, 2010

It is known that ultraviolet radiation is one of the most important risk factors contributing to non-melanoma and melanoma skin cancers. Athletes playing outdoor sports are exposed to a comparatively high amount of UV because of training and competition outdoors and thus athletes have an increased risk for cutaneous melanoma and other skin cancers.

A study has found that one in seven UK cricket players was urgently requested to see a specialist after discovering worrying moles during check-ups. For that reason the Professional Cricketer’s Association has organised screenings for all its members at dermatology specialists and already 15% of the male players were found to be in need of further investigation.

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Skin Cancer Awareness Month in the US

Tuesday, May 25th, 2010

May is Skin Cancer Awareness Month in the US, and it’s likely that the associated awareness campaign has come not a moment too soon. A recent study confirmed that non-melanoma skin cancer has reached epidemic levels in the US, with an estimated 300 percent increase in the number of skin cancers over the past decade and a half.

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Brutal: EPP and School sports

Friday, May 7th, 2010

During my high school years, age 12 – 18, I attended an all boys boarding school in Sydney.  The school was/is well known, among other things, for its sporting prowess.  Senior teams are almost unbeatable. This could be put down to the camaraderie built by living in close proximity to your team mates for the whole of the sporting season;  it could also be put down to the fact that every student was expected to play sport. In my time at the school, during the summer you could choose cricket, tennis or basketball and in winter you could choose any sport you wanted, as long as the only sport you wanted to play was rugby union!  Obviously, with a diagnosis of EPP (unheard of previously in the school’s experience) my parents met with the school’s head teachers and arranged for me to be excused from outdoor activity.

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Sun and health: The Wall St Journal faces off

Wednesday, April 28th, 2010

Earlier in the week, WSJ online published two articles exploring our relationship with the sun. This is something we’ve looked at extensively on the Clinuvel Blog (including the vitamin D debate), so we welcome discussion of it in the broader press. Squaring off are two senior WSJ journalists: Melinda Beck and Laura Landro.

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Shadow-jumping: EPP and work

Wednesday, April 21st, 2010


This week is Porphyria Awareness Week in the US, and guest blogger Mikey is discussing his experience of the impact that his EPP has had on his professional life.

Direct and indirect sunlight, from reflected light, is a real “killer” for me. If I can find a shadow, I can put exposed skin into that shadow to prevent that area getting burnt.

Unless you’ve got EPP you wouldn’t understand.

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Boiler suit, gloves, balaclava and a hat: EPP and the outdoors

Friday, April 9th, 2010

Clinuvel has invited guest blogger Mikey to discuss EPP on our blog; This is the second post in the series discussing the impact of EPP on life outdoors. We are grateful to Mikey for being able to share his experiences.

I was diagnosed with EPP when I was about 7.  Australia is a great country.  It is vast in its beauty and diverse in the hazards it provides!  One of those, for someone with EPP is the “great outdoors”.  I reckon this is the best country in the world.  I’ve lived in New York, and travelled extensively around the world – I’m always pretty pleased when I return home.

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Unbearable sunlight: EPP in childhood

Tuesday, March 30th, 2010

Clinuvel has invited guest blogger Mikey to discuss EPP on our blog; a series we will publish in the coming weeks. We are grateful to Mikey for being able to share his experiences.

My name is Mikey and I live in Sydney, Australia. I’m 44 and have had EPP all my life.  I grew up in Sydney with my parents, an older brother and a younger sister.  Mum and I both have EPP, but neither of my siblings nor my father had it.

I remember, as a child prior to diagnosis, my family didn’t know what was going on with me when I’d been in the sun too long – except my mum who had experienced the same things I was complaining about.

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Soybeans – a new sunscreen?

Thursday, March 25th, 2010

Scientists have announced a new method for creating a bio-based sunscreen active ingredient from refined soybean oil at the 239th National Meeting of the American Chemical Society (ACS).

The team, led by Dr Joseph Laszlo, has developed technology for converting soybean oil into an active ingredient for sunscreen products. It involves incorporating ferulic acid, found naturally in hundreds of plants, into soybean oil. The combination of ferulic acid and vegetable oil produces a water-resistant material capable of absorbing both UVA (320-400nm) and UVB (280-320nm) light. Both UVA and UVB play a role in causing skin cancer, while UVB is the direct cause of sunburn.

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