The Clinuvel AGM

Tuesday, November 24th, 2009

melbournetownhallAs many of you may know, this week saw Clinuvel hold its Annual General Meeting in the Melbourne Town Hall. As managing director I welcome these opportunities where I am able to meet and talk to the people whom Clinuvel considers integral to the company and its existence; the Board of Directors sees Clinuvel’s investors as unique. In Clinuvel, an investor has to fundamentally believe in the premise of offering pharmaceutical photoprotection, a novel option, an innovative approach to skin disorders.

In a meeting that would be considered short by international standards I was both excited and proud to present some of the achievements and milestones our team has reached this year, and lay out our plans for the next 12 months.

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Killing cancer in the UK

Thursday, October 8th, 2009

unitedkingdomA new initiative has just launched in the UK with the goal of increasing awareness and support for the more widespread use of photodynamic therapy (PDT). Compared to surgery and chemotherapy, PDT is a relatively simple, quick and effective treatment for certain types of cancer that we have covered previously on this blog.

Killingcancer.co.uk is a fundraising initiative aiming to create both a groundswell of interest and a pool of funds to support the development and access to PDT in the UK, to make it more readily available through the National Health Service (NHS). Through a mix of celebrity endorsements and patient stories they build an informative and compelling case for their cause.

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Light, life’s invisible paradox

Friday, August 28th, 2009

Photoart_0117During more than a decade of clinical research on Clinuvel’s proprietary drug afamelanotide, our teams have specialised in, and focused on, the study and importance of light absorption for our health and well-being.

However, light is regarded as an ‘optical paradox’: too little may result in vitamin D deficiency or seasonal affective disorder (SAD), while too much may result in skin cancer. In seeking answers from related fields, our in-house scientists often remark that human biology is unfortunate to lack green chlorophyll with its ability to efficiently process light into nutrition.

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Absolute light intolerance – Erythropoietic Protoporphyria (EPP)

Thursday, August 27th, 2009

blue_sunEPP is a rare condition, and the most acute indication for which we are exploring a clinical treatment with afamelanotide. Simply put, EPP is an absolute light intolerance brought about by a build up of photosensitive compounds in the skin of the sufferer.

It manifests itself during or after exposure to sunlight as swelling, burning, itching and redness of the skin. The major symptom however, and the most difficult to live with, is extreme and intense pain following exposure to light (particularly blue light, 400-410nm).

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Photodynamic Therapy (PDT) and phototoxicity

Wednesday, August 12th, 2009

photodynamictherapyIn Clinuvel’s search to demonstrate the effect of its drug to reduce symptoms caused by light in the visible and invisible spectrum, the team has started to carry out human trials in Photodynamic Therapy (PDT). This indication stands out among Clinuvel’s current series of clinical trials as it is aimed at reducing symptoms caused by another cancer treatment (adjunct treatment details can be found here).

PDT  begins with the administration of a photosensitizer containing molecules that are reactive to certain wavelengths of light, usually administered via intravenous injection.

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